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News Coverage of Glutathione, Whey Protein in Cancer


Fighting Cancer With Whey
From the article by Will Brink, in LE Magazine, November 1997

Whey and Cancer

Additional studies have been done on animals regarding cancer-causing chemicals to see what effects whey protein concentrate would have on cancer prevention or treatment. .. the rats fed whey protein concentrate showed fewer tumors and a reduced pooled area of tumors (tumor mass index).

The researchers found whey protein offered "considerable protection to the host" over that of other proteins, including soy. (McIntosh G.H., et al., Journal of Nutrition, 1995)

Even more exciting, in vivo research on cancer and whey showed whey protein concentrate inhibited the growth of breast cancer cells at low concentrations (Baruchel S. and Vaiu G., Anti Cancer Research, 1996).

Finally, and most importantly, a fairly recent clinical study with cancer patients showed a regression in some patient's tumors when fed whey protein concentrate at 30 grams per day. (Kennedy R.S., Konok G.P., Bounous G., Baruchel S., Lee T.D., Anti Cancer Research, 1995)

Whey and Glutathione

This new research using whey protein concentrate led researchers to an amazing discovery regarding the relationship between cancerous cells, glutathione (GSH) and whey protein concentrate....

In this new research it was found that cancer cells subjected to whey proteins were depleted of their glutathione, and their growth was inhibited, while normal cells had an increase in GSH and increased cellular growth.

These effects were not seen with other proteins. ........The exact mechanism by which whey protein achieves this is not fully understood, but it appears that it interferes with the normal feedback mechanism and regulation of glutathione in cancer cells.

It is known that glutathione production is negatively inhibited by its own synthesis. Being that baseline glutathione levels in cancer cells are higher than that of normal cells, it is probably easier to reach the level of negative-feedback inhibition in the cancer cells' glutathione levels than in the normal cells' glutathione levels.

See also:
Protocols: BREAST CANCER
LE Magazine January 1999

The Benefits of Whey
Whey protein as cancer treatment adjuvant, antibiotic, and anti-aging agent.

Whey Protein Power
Surprising success in the prevention and treatment of cancer is making whey protein a popular supplement.


Eat your whey: It may protect against prostate cancer
(28 May, 2003)

New research suggests that whey, a liquid byproduct from cheese production, may play a role in helping prevent prostate cancer. When Ohio State University food scientists treated human prostate cells in the lab with whey protein, cellular levels of the antioxidant glutathione increased.

Antioxidants such as glutathione have been shown to control cancer-causing free radicals. Cancer researchers suspect that the accumulation of free radicals plays a role in the development of prostate cancer.

In the current study, the Ohio State scientists found that treating prostate cells with whey protein elevated glutathione levels in the cells by up to 64 percent. The study appears in a recent issue of the journal Toxicology in Vitro.

"...whey proteins are rich in cysteine, an amino acid that increases glutathione in the prostate," Kent said. "...cysteine is the amino acid that helps create healthy glutathione levels in the prostate, and glutathione helps keep free radicals under control."


Protein Building Block May Prevent Breast Cancer

July 14, 2003 WASHINGTON, DC (Reuters Health) - High blood levels of cysteine, a protein building block, may protect against breast cancer, new research suggests.

Cysteine is classified as a nonessential amino acid, meaning that it doesn't need to be included in a person's diet, their own body can make it. Still, the new findings suggest that getting a little extra in the diet might be a good thing.

In the new study, women with the highest cysteine levels were 56% less likely to develop breast cancer than those with the lowest levels, study author Dr. Shumin M. Zhang, from Harvard Medical School in Boston, told Reuters Health.

Regardless of other known risk factors, as cysteine levels rose, breast cancer risk fell, Zhang found. However, the beneficial effects of a high cysteine level appeared to be strongest in lean women.

See also: AACR: High Cysteine Levels Linked to Lower Rates of Breast Cancer


Cancer Chemotherapy
LEF Disease Therapies Protocol

Whey proteins used in combination with glutathione appear to reduce the concentrations of glutathione in cancer cells, thereby making them more vulnerable to chemotherapy while maintaining or even increasing glutathione levels in normal healthy cells.

Glutathione production in cancer and healthy cells is negatively inhibited by its own synthesis. Since glutathione levels are higher in cancer cells it is believed that cancer cells would reach a level of negative-feedback inhibition for glutathione production more easily than normal cells.

Chemotherapy patients should consider taking 30 to 60 grams per day of whey protein concentrate 10 days before initiation of chemotherapy, during the chemotherapy, and at least 10 days after the chemotherapy session is completed.

Note: If blood testing shows that chemotherapy has suppressed the immune system, patients should insist that their oncologists use the appropriate immune restoration drug(s) as outlined in the Cancer (Adjuvant) Treatment Protocol.



A New Whey to Prevent Cancer?
Agricultural Research/October 2000 - By Thomas M. Badger

USDA Funded Research Finds That Soy, Whey Proteins May Help Prevent Breast Cancer
Release No. 0021.00
WASHINGTON, Jan. 20, 2000

Researchers at the Arkansas Children's Nutrition Center have found that whey and soy protein may help prevent breast cancer.

This research, funded by the U.S. Department of Agriculture, is featured in this month's "Cancer, Epidemiology, Biomarkers and Prevention," an official journal of the American Association for Cancer Research.

"This significant new research, although preliminary, suggests that adding whey or soy protein to the diet may help protect women and children from developing breast cancer," said Agriculture Secretary Dan Glickman.

In laboratory studies, researchers compared the protective effects of soy protein and whey protein against chemically induced tumors in the milk producing glands of rats.

They found that approximately 50 percent fewer rats had mammary tumors when fed a diet containing a processed whey protein as compared with rats eating a standard diet.

Data indicates that feeding rats diets made with whey protein can prevent mammary tumor formation in the major animal model of human breast cancer and illustrate the importance of dietary factors in disease prevention," said Badger, who has filed for a patent on the whey compound.


Wheying in on the Battle against Cancer
From "Finding the Whey" by Paula Frank

A study conducted in Taiwan suggests that whey protein isolate can stimulate production of glutathione, an antioxidant, in normal cells, thereby protecting them from toxicity, while at the same time reducing the glutathione level in cancer cells.

Cancer cells reportedly produce high levels of glutathione, which protects them from toxic substances and promotes resistance to anticancer drugs.

The laboratory study measured the growth of human liver cancer cells over a four day period in four different media:
1) normal medium
2) A patent-protected whey protein isolate
3) Baicalein (a potential anti-cancer drug)
4) Whey protein isolate and baicalein combined.

According to researchers, treatment with baicalein significantly reduced the viability of cancer cells.The combination of whey protein isolate and baicalein was even more effective.

Thirteen times more cancer cells underwent apoptosis (cell death)in the group treated with baicelein alone versus the control group, whereas 45 times more cancer cells underwent apoptosis in the combination group of baicalein and Immunocal in comparison to the control.

The best possible scenario for a cancer-treatment patient is to reduce the level of glutathione in cancer cells, while increasing or at least maintaining levels in normal, healthy cells. Initial research results indicates that whey protein does just that.

Source: Tail WY et al.
Nutr and Cancer, 38(2): 200-208, 2001 summary by Judith Jarvis,MS, RD National Dairy Council, Rosemont, Ill.


Improved Cancer Treatment May Be Just a Glass of Milk A "Whey"
Press Release from the National Dairy Council

A recent study found that whey proteins – which are pure, high-quality proteins found in cow’s milk – may enhance the effectiveness of the potential anticancer drug, baicalein.

The researchers conducted the study using a whey protein isolate and found that nearly 45 times more human liver cancer cells died when they were treated with both the whey protein and baicalein than the control group.

In addition, whey protein isolate enhanced the cancer killing effect of the anti-cancer drug by 13 times. The researchers conclude that whey proteins may provide some benefit in cancer treatment.

Reference:
Enhancing Effect of Patented Whey Protein Isolate on Cytotoxicity of an Anticancer Drug.
Tsai, W.Y. et al.
[Nutrition and Cancer. 2000; 38(2): 200-208.]


Glutathione: New Supplement on the Block
(Living Better Feature - WebMD)
(Extracts from the article by Alison Palkhivala)

Who wouldn't like to get their hands on a naturally occurring substance that acts as an antioxidant, an immune system booster, and a detoxifier? ..... The strong antioxidant effect of glutathione helps keep cells running smoothly.

"If you look in a hospital situation at people who have cancer, AIDS, or other very serious disease, almost invariably they are depleted in glutathione...

Glutathione is probably not well absorbed into the body when taken by mouth......A more practical solution is to take the precursors -- that is, the molecules the body needs to make glutathione -- rather than glutathione itself......

Bounous has developed a glutathione-enhancing product, which is made up of glutathione precursors, mainly the amino acid cysteine.

The best studies have been conducted in cancer. One study involved women with ovarian cancer who were being treated with chemotherapy.

Some of the women were also treated with intravenous glutathione.Those given the glutathione not only had fewer side effects from the chemotherapy but also had better overall survival rates.......

Bounous says his research has demonstrated that taking the patented bonded cysteine supplement actually lowers glutathione in cancer cells while increasing it in normal cells. As a result, the cancer cells are more vulnerable to chemotherapy, and the normal cells are protected.

Myriam Abalain of Montreal, Canada, is one of the many people who have taken Bounous' bonded cysteine supplement to combat cancer........a hysterectomy was her only option, but she hesitated to have such major, life-altering surgery.......For more than two years, her condition remained stable. Then a friend suggested she try the bonded cysteine supplement.

After eight months of taking the supplement, her physician could no longer detect any precancerous cells......Even Bounous acknowledges there's no real proof his product cured her cancer, but he's working on conducting good clinical research, comparing individuals with cancer taking glutathione to those who are not.

They all acknowledge that people with severe diseases known to be associated with low glutathione levels, such as AIDS, may well benefit from the bonded cysteine supplement.

For her part, Myriam Abalain is still taking the bonded cysteine supplement and feeling fine. "I'm doing pretty good now," she says. "I'm in better shape than ever!


Scientists find key to 'wasting syndrome' seen in cancer, AIDS
From the Department of Veterans Affairs website
Published 9 a.m. (ET) Monday, Dec. 9, 2001

Department of Veterans Affairs researchers and colleagues have discovered a biochemical mechanism that may explain wasting syndrome, a condition that causes severe weight loss and weakness in patients with chronic inflammatory diseases and often hastens their death.

Scientists in San Diego pinpointed the biological chain of events that caused wasting in mice, then identified the same process in liver tissue from cancer patients.

Dr. Chojkier and lead author Martina Buck, Ph.D., of VA, UCSD and the Salk Institute for Biological Studies, described the steps by which tumor necrosis factor (TNF) alpha, an immune-system protein, prevents the production of albumin.

Low levels of albumin, a critical protein made in the liver, is a keynote of wasting.

The researchers found several ways of stopping the downward spiral caused by TNF- alpha. One way was to treat TNF-alpha-enhanced mice with vitamin E and other antioxidants. "If we block oxidative stress, we normalize everything," explained Dr. Chojkier.

According to Dr. Chojkier, a gastroenterologist and liver specialist, antioxidants such as vitamin E might halt wasting in humans if these supplements were delivered in very high amounts-or even better, if they were targeted to the liver. "One solution will be to find a liver-specific antioxidant," he said. "With the technology we have today, this is very feasible. We believe this will provide an exciting avenue for intervention."

Note: Glutathione is a the most important liver-specific antioxidant and also acts to reconstitute vitamins C and E after they have been oxidized, and therefore plays a determinant role in their function.


Milk Protein Destroys Cancer Cells
12/12 The Daily News

A milk protein — lacto ferracin — can zap deadly cancer cells, particularly in leukemia tumours, Dalhousie University scientists have found in a new study. The most encouraging result is that the protein seems to kill only the cancer cells, not healthy cells.


News from Sweden:
Human Breast Milk Kills Cancer Cells!
from the June,1999 issue of Discover Magazine

In the June, 1999 issue of Discover Magazine, on the front cover; News from Sweden: Human Breast Milk Kills Cancer Cells! In this article, Peter Radetsky interviews Dr. Catharina Svanborg who is a physician and immunologist at Lund University in Sweden.

She talks about her discovery with a team of researchers that Human Breast milk in vitro, killed every type of cancer cell they tested it against. This included lung cancer, throat cancer, kidney cancer, colon cancer, bladder cancer, lymphoma and leukemia. The research has been ongoing for seven years.

..they pinpointed the killer of the cancer cells, which turned out to be ALPHA- LACTALBUMIN!

Got cancer killers?
DISCOVER Vol. 20 No. 6 (June 1999)

Breast-feeding protects babies from cancer, but no one knows quite how. So when biologists in Catharina Svanborg's lab saw mothers' milk kill cancer cells, they knew they were onto something big.

When Catharina Svanborg and her research associates began mixing mothers' milk and cancer cells together seven years ago, she wasn't looking for a cure for cancer; she was after a way to fight germs.

Nevertheless, the physician and immunologist at Lund University in Sweden has discovered that a previously taken-for-granted component of ordinary human breast milk compels cancer cells--every type of cancer cell tested--to die.


More references:

Nutritional Supplementation For Cancer, Part 1
Stephen Byrnes, PhD, RNCP

Whey Protein Shown Effective in Preventing, Treating Breast Cancer
Prepared Foods Online Newsletter - October 8 , 2001

Breast Cancer: Whey Protein May Be Twice As Effective As Soy As Preventative/Treatment
Women's Health Weekly - October 25-November 1, 2001

Soy, whey proteins may lower cancer risk

Prevention of Cancer with Whey Protein

Cancer Prevention with Whey Protein (Prev 1)

Potential Anti-cancer activity of Milk and Milk Components

Alpha-Lactalbumin

Breast milk component kills cancer cells


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